Endocrine Abstracts

Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders. In women, vitamin D status has been associated with in vitro fertilization (IVF) outcome, features of polycystic ovarian syndrome (PCOS), endometriosis, and sex hormone steroidogenesis. In detail, cross-sectional data suggest a regulatory role of vitamin D in PCOS-related aspects such as ovulatory dysfunction, insulin re...

Background: The aim of this study was to evaluate salivary androgen measurements via liquid chromatography-mass spectrometry as a non-invasive tool for the diagnosis of polycystic ovary syndrome (PCOS) and the assessment of metabolic health.Methods: Saliva and serum samples of 274 patients with PCOS fulfilling Rotterdam criteria and 51 BMI-matched, premenopausal, healthy controls were analysed for steroid hormones using liquid chromatography/mass spectro...

Apart from the crucial effects of vitamin D on bone health, vitamin D deficiency has been associated with various chronic conditions such as metabolic or reproductive disturbances. The polycystic ovary syndrome (PCOS) represents the most common endocrine disorder among women of reproductive age. Women affected by PCOS frequently suffer from oligo- or anovulation as well as from obesity and insulin resistance. There is accumulating evidence showing an association of vitamin D s...

BackgroundMetformin is a widely used and effective agent in type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome (PCOS). Yet, the mechanisms of action and the occurrence of side effects (e.g. abdominal bloating and pain), are still poorly understood. Since organic cation transporters (OCTs) are responsible for the hepatic and renal transport of metformin, we investigated a series of short nucleotide polymorphisms (SNPs) in the OCT genes in PCOS ...